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Alpha lipoic acid (ALA) is a natural substance found in some foods and is also synthesized in the body

It enhances the activity of immune cells and also functions as an antioxidant within them

Studies have shown the positive effects of using DNMT inhibitors, HDAC inhibitors, and extracellular vesicles loaded with miRNAs in preventing mutant huntingtin-induced neurotoxicity, emphasizing the potential roles of epigenetic dysregulations in HD

Apart from development, glutathione is crucial for stress response by (i) neutralizing radicals, (ii) participating in heavy metal tolerance, either directly or as a constitutive element of phytochelatins, (iii) contributing to the regeneration of antioxidant molecules such as ascorbate and -tocopherol, and (iv) providing electrons and protons to glutathione transferases (GSTs) or to peroxiredoxins, both with and without the involvement of glutaredoxins (Grxs) for peroxide removal (Rouhier et al., 2008)