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For example, chemotherapy-receiving breast cancer patients with elevated levels of p16INK4a senescent marker were found to experience most fatigue (Sanoff et al., 2014

Increasing evidence indicates that IDO activation and IL-10 production can be induced by the same stimuli, leading to the view that the anti-inflammatory and tolerogenic actions of both proteins may be at least complementary and potentially synergistic (186, 187)

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Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimers V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner