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The other non-canonical effects of the v-ATPase that are not readily attributable to its proton-pumping activity include membrane fusion, pH sensing, amino-acid-induced activation of mTORC1, and scaffolding for protein-protein interaction 42,54

doi: 10.1016/j.idc.2021.03.011 13 ArendrupM

Haque SM, Rahman H, Rahman N, Azmi SN, Ashwaq O, Wabaidur SM, Siddiqui MR, Alam M (2023) Application of Box-Behnken design combined response surface methodology to optimize HPLC and spectrophotometric techniques for quantifying febuxostat in pharmaceutical formulations and spiked wastewater samples

An update on the role of Nrf2 in respiratory disease: molecular mechanisms and therapeutic approaches