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410 Elevated arginase levels lead to L-arginine depletion, decreased output of NO, increased ROS, and impaired endothelium-dependent vasodilation

285 Additionally, the cross-linking of collagen fibers, a process essential for the mechanical stability and durability of the ACL, is influenced by the availability of nutrients that support enzymatic activity

Adequate vascular supply is essential for delivering oxygen, nutrients, and immune cells to healing tissues while removing metabolic waste products

Accordingly, Masson staining revealed that recombinant CXCL10 treatment sharply increased fibrosis in the CXCL10 group, whereas IL18R1 antibody treatment reversed fibrosis to levels close to those of the control in the 10+18ab group (Fig