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10.1128/MCB.24.12.5475-5484.2004 Mol

see Additional file 2 for the analytic results for all genes)

Each deacetylation cycle of SIRT1 consumes one NAD molecule, producing acetyl-ADP-ribose (1-O-acetyl-ADP-ribose or 2- and 3-O-acetyl-ADP-ribose) and nicotinamide as byproducts (Liu et al., 2022a