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PATHOPHYSIOLOGY AND MECHANISMS Migraine is a complex and disabling neurological disorder, more prevalent in women, whose pathophysiology involves neurovascular mechanisms, mitochondrial dysfunction, neurogenic inflammation, and oxidative stress

Individuals taking certain medications that include nicotinic acid, theophylline, bile acid-binding resins, methotrexate, and L-dopa all interact with folate and may increase risk for folate deficiency

The MGBA constitutes a complex bidirectional communication network that involves interactions between gut microbiota, the intestinal barrier, the immune system, the vagus nerve, the enteric nervous system, and the central nervous system (Loh et al., 2024)

When vitamin C donates electrons to neutralize free radicals, glutathione can restore vitamin C to its active form, and vitamin C can do the same for glutathione, creating a continuous antioxidant cycle