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Blocking this receptor abolished the antidepressant effect of CBD, indicating that its effects are mediated by the serotonergic pathway and are associated with microRNA modulation in the vmPFC ( There is growing evidence that CBD is a promising candidate for the treatment of depression, acting through complex mechanisms that involve the modulation of multiple receptors, including CB1, CB2, G-protein-coupled receptor 55 (GPR55), 5-HT1A, and PPAR (Miao et al., 2025)

Circulation 103 (23), 27992804

Bick AJ, Louw-du Toit R, Skosana SB, Africander D, Hapgood JP (2021) Pharmacokinetics, metabolism and serum concentrations of progestins used in contraception