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(DiSilvestro et al., 2012) The majority of curcumin passes through the body unchanged, and the remaining amount is quickly metabolised by the liver, meaning little or no curcumin reaches target tissues in the free, active form

There was also a tentative observation of increased epithelialization, a process essential for the regeneration of the skin's outer layer, in these experimental conditions

Declarations Acknowledgement The authors acknowledge the technical assistance of Prof Ngwu Nwachukwu of the Department of Biochemistry, School of Biological Sciences, Federal University of Technology, Owerri, Imo State, Nigeria

Additionally, allicin-loaded hydroxyapatite scaffolds have been fabricated for bone tissue engineering applications, demonstrating enhanced release profiles, cytocompatibility, and significant antibacterial activity against Staphylococcus aureus