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They further demonstrated that treatment with the STING inhibitor, H151, in their murine model showed a decrease in lung inflammation at late time points and a reduction of viral loads

The most frequent AEs (2% in any treatment group) that occurred more often in the ritlecitinib groups than placebo and were dose-related included diarrhea, acne, urticaria, rash, and dizziness.21Table 2 lists AEs that occurred in 5% of patients in any treatment group within the all-exposure cohort.25 Adverse events of special interestInfections The incidence rate (IR) of serious infections was low across the ALLEGRO program