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Potential Benefits & Side Effects Observations from preclinical and limited clinical literature

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One reason for the failures could be that 50% of AD patients exhibit -synuclein pathology, while 30% show TDP43 pathology (Robinson et al., 2018)

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Pharmacogenomic testing of thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) genotypes minimizes the occurrence of myelosuppression

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