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Oxidative Medicine and Cellular Longevity, 2021 , Article 1987588

Cocaine neurotoxicity and neurological damage stem from several mechanisms, including mitochondrial dysfunction (Poon et al., 2007), neuroinflammation (Moran et al., 2005), and autophagy ( 3.1 Vascular effects of cocaine Cocaine impairs vascular function by causing vasoconstriction, reducing cerebral blood flow, and decreasing tissue oxygenation