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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

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Shen H, Shih J, Hollern DP, Wang L , Bowlby R, Tickoo SK, Thorsson V, Mungall AJ, Newton Y, Hegde AM, Armenia J, Snchez-Vega F, Pluta J, Pyle LC, Mehra R, Reuter VE, Godoy G, Jones J, Shelley CS, Feldman DR, Vidal DO, Lessel D, Kulis T, Crcano FM, Leraas KM, Lichtenberg TM, Brooks D, Cherniack AD, Cho J, Heiman DI, Kasaian K, Liu M, Noble MS, Xi L, Zhang H, Zhou W, ZenKlusen JC, Hutter CM, Felau I, Zhang J, Schultz N, Getz G, Meyerson M, Stuart JM, Research Network CGA, Akbani R, Wheeler DA, Laird PW, Nathanson KL, Cortessis VK, Hoadley KA

112,113 Finally, the GATOR1 complex appears to be necessary for rapid and robust mTORC1 inhibition following growth factor withdrawal