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The role of ferroptosis in the metastatic niche (e.g., bone and lung metastases of RCC) is also unaddressedwhether the niches microenvironment (e.g., hypoxia and iron availability) modulates ferroptosis to support metastatic outgrowth requires clarification

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Cysteine and ascorbate cause reductive cleavage of the SN bond in GSNO and other S-nitrosothiols