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This enhanced MET signalling results from: (i) overexpression of MET [28,29,30,31,32,33,34,35,36], (ii) constitutive activation of MET [28, 29, 37], (iii) activation sustained by HGF [30, 37], and (iv) secretion of HGF, not normally expressed by epithelial cells, leading to an autocrine activation loop [28, 33, 34, 37]

Tirzepatide in T2D: SURPASS Clinical Trial Program Results from SURPASS-15 have been published [8,9,10,11,12] and reviewed extensively elsewhere [16,17,18,19], so are only briefly summarised here

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Hsieh, M., Liu, H., Wang, C., Huang, H., Lin, Y., Ko, Y., Wang, J., Chang, V., & Pang, J