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Vitamin B12 Biochemistry and (Patho) Physiology Encyclopedia MDPI Glossitis and hyperpigmentation of hands due to Vitamin B12 deficiency. B12 leads to melanin synthesis more frequently in people with darker skin. Skin hyperpigmentation was reversed with B12 replacement Homocysteine: Diagnostic Significance and Clinical Insights Advanced Health Academy Vitamin B12 Deficiency and the Nervous System: Beyond Metabolic DecompensationComparing Biological Models and Gaining New Insights into Molecular and Cellular Mechanisms PMC
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