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The collagen fibrils in P2 and P5 had very irregular contours and a branched appearance with irregular interfibrillar spaces, but they more or less maintained their cylindrical appearance

Studies revealed that cytochrome c leakage from mitochondria initiates apoptotic signaling cascades, ultimately resulting in cell death (Chen et al., 2006)

Mitochondrial dysfunction in arsenic toxicity Arsenic disrupts mitochondrial homeostasis through activation of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3)-transforming growth factor-beta 1 (TGF-1)/Suppressors of Mothers Against Decapentaplegic (SMAD) signaling pathway, which promotes renal inflammation and fibrosis

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