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Small molecules targeting H3K9 methylation prevent silencing of reactivated FMR1 alleles in fragile x syndrome patient derived cells

Abbreviations BV: Bee venom T-47D: Human breast ductal carcinoma Resistance T-47D: Resistance human breast ductal carcinoma Panc1: Human pancreatic cancer Pc3: Human prostate cancer MCF 10A: Non-malignant breast cell LD50: The median lethal dose Bcl-2: B-cell lymphoma 2 BAX: Bcl-2-associated X protein SDS: Sodium dodecyl sulfate KDa: Kilodalton BC: Breast cancer PI: Propidium iodide FITC: Fluorescein isothiocyanate PLA2: Phospholipase A2 TNBC: Triple-negative breast cancer cells HER2: Human epidermal growth factor receptor-2 Caspases: Cysteine-dependent aspartate-directed proteases EGFR: Epidermal growth factor MAPK: The mitogen-activated protein kinase Akt: Protein kinase B HCL: Hydrochloric acid DMSO: Dimethyl sulfoxide ELISA: Enzyme Linked Immunosorbent Assay DNA: Deoxyribonucleic acid DOX: Doxorubicin PBS: Phosphate-buffered saline RNA: Acid EAC: Ascites carcinoma of Ehrlich IP: Intraperitoneally GSH: Glutathione SOD: Superoxide dismutase MDA: Malondialdehyde TIR: Tumor inhibition ratio TBS: Tris-buffered saline AST: Aspartate aminotransferase ALT: Alanine transaminase ATI: Acute tubular injury TBS: Tris-buffered saline U87: Human glioblastoma cell HCT116: Colon cancer cells 8-MG-BA: Human glioblastoma cell A1235: Human glioblastoma cell MDA-MB-231: Breast cancer cell MCF-7: Human breast cancer cell SW480: Colon cancer cell Cyt C: Cytochrome C P53: Tumor suppressor protein TNF: Tumor necrosis factor PI3Ks: Phosphoinositide 3-kinases mTOR: The mammalian target of rapamycin NF-B: Nuclear factor kappa light chain enhancer of activated B cells HeLa: Cervical cancer cells ROS: Reactive oxygen species BAX: Bcl-2-associated X protein Bcl-xL: B-cell lymphoma-extra large ER: Estrogen receptor alpha MAPK: Mitogen-activated protein kinase JNK: Jun N-terminal kinase DR: Death receptor PARP: Polyadenosine diphosphate-ribose polymerase References Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Pieros M, Znaor A, Bray F (2021) Cancer statistics for the year 2020: an overview

Thus, common detoxification enzymes from an increased metabolism are carboxylesterases (CarE), cytochrome P450 (CYP) and glutathione-S-transferases (GSTs), while from target-site mutations are acetylcholinesterases (AChE)

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