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Secondary causes of HTG can also include T2DM, hypothyroidism, pregnancy, hepatosteatosis, significant weight re-gain after weight loss, nephrotic syndrome and some medications [1, 4, 12]

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In the TMLHE gene knockout mouse model, the carnitine biosynthetic pathway is inhibited due to the loss of TMLD activity in the liver, affecting the availability of carnitine in the heart, significantly reducing the rate of synthesis of LCACs, and contributing to the protection of mitochondrial function after myocardial IRI [215]

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