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The combination of GLP-1 and GIP activation is what separates tirzepatide from pure GLP-1 agonists like semaglutide, and clinical data suggests the dual mechanism produces superior weight loss outcomes

Policarpo RL, Decultot L, May E, Kuzmi P, Carlson S, Huang D, Chu V, Wright BA, Dhakshinamoorthy S, Kannt A (2019) High-affinity alkynyl bisubstrate inhibitors of nicotinamide N -methyltransferase (NNMT)

Importantly, these body weight changes were not attributable to differences in food intake across the groups, as all treatments showed similar food consumption patterns in both lean and obese mice

[4] Niacinamide (vitamin B) forms the coenzymes NAD and NADP, which are involved in hundreds of oxidation-reduction reactions in cells