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Matschke et al., 2016), with a naturally high resistance to treatment due to an augmentation in hypoxia-inducible factor-1 alpha (HIF-1) (Hsieh et al., + increases with distance from the blood vessels due to the distance of diffusion and the increased production of lactate from anaerobic cells, creating a highly acidic region (Fang et al., 2000

Evidence-based treatment for fatty liver disease prioritises 710% body weight loss, dietary changes, and management of diabetes and dyslipidaemia