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Unlike hepatocellular carcinoma, ferroptosis is largely governed by system Xc heterodimeric transporter (SLC7A11 and SLC3A2) inhibition and basal ROS stress [148], glioblastoma exhibits a GPX4-dependent survival phenotype, particularly in GSCs

It avoids major drawbacks of conventional oral (gastrointestinal side effects, low drug bioavailability, and need for multiple dosing) or parenteral routes (invasiveness, pain, and psychological stress and bio-hazardous waste generated from needles), thereby increasing patient appeal and compliance

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Tomblin V., Ferguson L.R., Han D.Y., Murray P., Schlothauer R

Ice applied to the injection site for 2 to 3 minutes before injection can reduce pain