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Abstract Neutrophils are predominant immune cells that protect the human body against infections by deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and neutrophil extracellular trap (NET) formation

[86,87,88,89] (Figure 19)

7b), presumably because they could generate GSH from bacteria-derived Cys and at the expense of other Cys consuming processes in the cell

J Clin Invest 71:258267, 1983 Russo A, Mitchell JB: Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation, Cancer Treat Rep 69(11):12931296, 1985 Griffith OW: Mechanism of action, metabolism and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis