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AMP Kinase (AMPK): AMPK, a key energy-sensing kinase, modulates the activity of glutamine-PRPP amidotransferase to ensure that nucleotide synthesis is in sync with cellular energy status

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This approach would allow for precise regulation of HO-1, inhibiting its harmful effects while preserving its antioxidative function

To assess the potential role of PVN Glu neurons in modulating morphine-induced constipation, we directly infused morphine into the bilateral PVN through implanted cannulas (Fig