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Clinical Classification of Chronic Venous Disease C0: No visible or palpable sign of venous disease C1: Spider veins or reticular veins (veins that feed spider veins) C2: Varicose veins C3: Edema (swelling) C4: Changes in skin and tissues A: Pigmentation or eczema B: Thickening, hardening, swelling, redness, inflammation, scarring C5: Healed venous ulcer C6: Active venous ulcer Note: Some potential complications of venous disease, such as DVT, can occur even in people who have no overt signs

Ding S, Chen X, Shen KJCC

early, intermittent, or persistently enhanced cell proliferation and reduced apoptosis

Effect of direct cold atmospheric plasma (di cap) on microcirculation of intact skin in a controlled mechanical environment