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To assist cancer cells overcome oxidative stress barriers during carcinogenesis, mutations in KEAP1 trigger the nuclear factor erythroidrelated factor 2 (NRF2) antioxidant program and work in tandem with mutant KRAS to drive the development of lung adenocarcinoma (LUAD) [103, 104, 105, 106, 107, 108]

Furthermore, DIM helps shunt estrogen metabolites down a safer pathway by modifying the active cytochrome P450 enzymes

Rifabutin act as a weaker inducer than RIF, with 23 times lower effect on CYP3A4, making drug interactions less impactful in clinical practice (AIFA - Ricerca Farmaco, 2024)

Human Molecular Genetics, 25 (16), 34763490