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Oncogene 2023, 42: 8398

Disruption of methylation was suggested by several lines of evidence

However, the contribution of GSH degradation to chemoresistant phenotypes, remains unclear

Here, we first summarize the canonical CoQ 10 biosynthetic pathway and provide a comprehensive overview of both established and emerging CoQ 10 oxidoreductases, such as FSP1, DHODH, SQOR and additional enzymes, emphasizing their biochemical roles in ferroptosis regulation