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Since CPP-CAND was designed to interfere with the FOXO4-p53 interaction, we investigated the disruption of FOXO4-p53bp1 foci in the nucleus of senescent cells after CPP-CAND treatment

EARLY WORK DEFINING THE INSULIN-GH-IGF-AXIS Daughaday realized that the mitogenic effect of GH in the growth plate was not direct but mediated by Insulin-like Growth Factor-I (IGF-I), at that time named sulphation factor or somatomedin C (1)