Fmoc-Val-Cit-PAB(m-PEG8) 4' 866 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

866 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

CC-92480 promotes rapid and extensive degradation of Aiolos/Ikaros than s lenalidomide and pomalidomide

335 SMILES BrCCCCCCCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

PEG linkers enhance water solubility and provide spatial separation to minimize steric hindrance during binding interactions

Fmoc-Val-Cit-PAB(m-PEG8) 4' 866 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned