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24 Copper homeostasis is tightly regulated in cells To maintain Cu homeostasis at the cellular level, intracellular Cu content is regulated by a complex network of Cu-dependent proteins, including cuproenzymes, Cu chaperones, and membrane transporters

Understanding this helps contextualize the temporary worsening some researchers experience

They can suggest ways to manage or prevent further discoloration

Interestingly, our in silico database search of enriched ABR genes had hits to the Gram-negative bacteria family of Enterobacteriaceae and in some cases specific genera of Salmonella , Escherichia , Klebsiella , Shigella , Enterobacter and Citrobacter