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Soudi Cytokine.2025

Combined triad-GSH metabolism model simulations: impact of quinone metabolism on glutathione homeostasis The model was used to investigate how single vs constant 50 M exposure of doxorubicin influenced blood and cytosolic GSH and cysteine (Cys) levels, over a 10-hour time-span, shown in Fig

found that highly metastatic CRC cells primarily rely on glutamine-driven TCA cycle activity to sustain energy production, whereas low-metastatic cells tend to depend more on glycolysis [94]