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130 The AuS binding is a well-known covalent bond where thiol groups (soft Lewis base) readily adsorb onto the reduced gold surface (soft Lewis acid) based on the Hard and Soft Acid and Base (HSAB) theory

It is a biological process that may contribute to inflammation and tissue injury when the balance between oxidants and antioxidants remains disrupted

However, in diabetes, oxidative stress and chronic inflammation alter IRP activity, leading to iron metabolism dysregulation, iron overload, and increased ferroptosis ( 2.3 Role of oxidative stress in diabetic cardiomyopathy In DCM, the disruption of iron homeostasis and persistent oxidative stress are key drivers of ferroptosis (62)

101, 110 (2016), Application(s): Western blot analysis, mouse SN tissues, Abstract Delivery of Soluble Heme Oxygenase 1 Cell-Penetrating Peptide into Liver Cells in in vitro and ex vivo Models of Cold Ischemia: A.B