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The endothelium regulates: Vascular tone and blood pressure Platelet aggregation and clot formation Inflammatory responses Cholesterol transport and lipid metabolism Nitric oxide (NO) production When this thin layer of cells becomes damagedby high blood pressure, insulin resistance, toxins, poor diet, or chronic inflammationit sets the stage for: Atherosclerotic plaque formation Vascular stiffness Impaired blood flow Increased clot risk Peptides offer a novel way to reverse endothelial damage and restore vascular health at the cellular level

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Extracellular ATP activates c-jun N-terminal kinase signaling and cell cycle progression in hepatocytes

This causes a build-up of uric acid and increases the risk for gout