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The preferable timing of the divided dose for the convenience of the patient and to assist the patient in remembering to take the dose is that tablets should be taken upon waking and approximately 12 hours later before sleeping

Nature 426 , 620 (2003)

Conversely, if you have used the direct method, try the indirect method

Overexpression of superoxide dismutase protects plants from oxidative stress (induction of ascorbate peroxidase in superoxide dismutase-overexpressing plants)