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Animal models are the main tool to investigate etiology, molecular mechanisms and screening for pharmacological therapies

Since skin steroidogenesis can be modulated by external factors and is locally restricted, there is a tremendous potential for novel topical therapeutic approaches targeting skin estrogen biosynthesis to achieve local estrogen healing benefits without off-target effects which are undesirable in both men and women, as explained in the following section

The mdx mice at this age have stably regenerated muscles with minor markers of past regeneration events particularly central nuclei instead of peripheral muscle nuclei

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