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In young men, FOXO4 was predominantly found in the cytoplasm of Leydig cells, whereas in elderly men, it was primarily localized in the nucleus

Further characterization of the HUVEC/NHDF approach shows that the pharmacological and physiological effects on endothelial cell biology are highly translatable to previous in vivo characterizations, exemplified by DLL4/Notch inhibition resulting in increased branch point formation late in the angiogenic process [3941]

TNF-alpha induced shedding of the endothelial glycocalyx is prevented by hydrocortisone and antithrombin

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