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For instance, gene editing technologies like CRISPR-Cas9 present exciting possibilities for addressing age-related diseases, but concerns regarding off-target effects, long-term safety, and the ethical implications of genetic modifications need to be thoroughly addressed before such interventions can become mainstream (Caobi et al., 2020)

In contrast, females do not exhibit this cytosolic inhibitory response and show impaired regulation of GR nuclear translocation, associated with disorganized localization of FKBP51, which becomes predominantly nuclear (Palumbo et al., 2020)

In patients with NAFLD, fat accumulates primarily in the form of TG within the liver (Jacome-Sosa and Parks, 2014)

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