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Avoid Rapid Dose Escalation Increasing doses too quickly may increase the chance of nausea, fatigue, or headaches

As a result, pyridoxine deficiency can lead to relevant neuropsychiatric manifestations, such as reduced neurotransmitter synthesis, depression, epilepsy, premature aging of neurons, paresthesias, cerebrovascular diseases, cognitive impairment and carpal tunnel syndrome (58) In contrast, pyridoxine may have therapeutic potential for treating depression or aggressive behavior, since pyridoxine plays a crucial role in the tryptophan-serotonin pathway (61, 62)

Heffernan 2001a No hyperglycaemia observed in animal models even at doses producing significant fat oxidation

Knowing the difference helps you stay calm and take the right action if needed