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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2016) 167:829842.e13

For example, arachidonate 12-lipoxygenase, 12S type (ALOX12) inactivation abrogated p53-mediated ferroptosis in cancer cells, and ALOX12 also nullified p53-dependent inhibition of tumor growth in xenograft model mice[40]