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The following formula was used: Monoamines level determination According to Ciarlone 59 , weighted samples of cortical tissue were added to cold acidified butanol (3 mL) in a small beaker and homogenized for 30 s before being placed in plastic tubes and centrifuged at 5000 rpm for 5 min

Clinical Studies Mild To Moderate Alzheimers Disease The effectiveness of ARICEPT as a treatment for mild to moderate Alzheimers disease is demonstrated by the results of two randomized, double-blind, placebo-controlled clinical investigations in patients with Alzheimers disease (diagnosed by NINCDS and DSM III-R criteria, Mini-Mental State Examination 10 and 26 and Clinical Dementia Rating of 1 or 2)

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10.1038/clpt.1989.109 Clin