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Antacids and histamine-2-blocking agents are currently the cornerstones of effective prophylaxis, but because they have been linked to nosocomial pneumonias caused by bacterial overgrowth in the stomach, research into alternative prophylactic agents like sucralfate and prostaglandins that do not alter gastric acidity is ongoing

Still, high doses can act as prooxidants, meaning they might generate reactive oxygen species under certain conditions

tabacum cell suspension to elevated temperature (55C) also resulted in increased GR activity (Locatto et al., 2009)