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Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations

Directly supplementing with oral reduced glutathione (L-GSH), however, presents a fundamental pharmacokinetic challenge: GSH has a plasma half-life of approximately 1.6 minutes, undergoes rapid hydrolysis in the gut by intestinal -glutamyl transpeptidase (-GT), and cannot cross cell membranes intact requiring full breakdown into constituent amino acids and intracellular resynthesis

Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R, et al

However, severe upper abdominal pain that radiates to the back, especially if accompanied by nausea, vomiting, and fever