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As explained later, these components can cross-talk with other pathways such as the MAPK/ERK1/2 (mitogen activated protein kinase/extracellular signal-regulated kinase 1/2) and PI3/Akt (phosphoinositide 3-kinase/protein kinase B) signaling cascades causing changes in gene expression and modifying cell metabolism and proliferation (47)

The carrageenan-induced increase in the levels of the cytokine-inducible nitric oxide synthase, IL-1, and IL-6 was abrogated following treatment with CBC

Clinical manifestations include negative symptoms, such as affective flattening, social disengagement, and avolition, as well as positive symptoms, including hallucinations and delusions

Yi xue ban = Journal of Central South University