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Whilst targeting first launches in 2025, these timelines are at risk if the health authorities require full clinical development programmes to be completed for a change of the propellant, when there are no other substantial changes in the formulation The pharmaceutical industry needs to respond with lowerGWP alternatives whilst at the same time, regulators need to work with the industry to expedite the approval of such new products if essential patient medication is not to be put at risk in the Western world

The FDAs letters suggest that claims suggesting equivalence to approved drugswhether direct or impliedmay face enforcement action

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Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer