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Traumatic neural injury mechanisms include notable down-stream consequences on excitotoxic injury, cerebral vascular flow, diffusion along axonal pathways, and activation of microglia

In whole, the data of different studies show that the concentration of 4-HNEs in the cell is important for the activation of the cell cycle and signal cascades regulating cell differentiation, proliferation, and apoptosis, the level of 4-HNEs being strongly dependent on the activity of GSTA4-4 both in the cytoplasm and in the mitochondria

There are multigenic families of APX in higher plants for e.g., Arabidopsis has 9 APX genes (AtAPX1-AtAPX6, sAPX, tAPX, lAPX) and Oryza sativa has 8 isozymes ( Os APX1- Os APX8), having two APX each in cytosol, peroxisome, chloroplast and mitochondria (Table 1)

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