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Furthermore, thymoquinone and curcumin combination also prevented cisplatin-induced kidney injury by attenuating NF-B, KIM-1 and ameliorating Nrf2/HO-1 signaling ( 5.2 Aristolochic Acid (AA)-Induced Nephrotoxicity Ingestion of Chinese herbal medicines containing AA can induce aristolochic acid nephropathy (AAN) which is a rapidly progressive tubulointerstitial disease (Vanherweghem et al., 1993)

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Topical serums produce localized surface-level effects in the skin layers they penetrate, which is limited by the skin barrier