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(2016) reviewed 54 studies and found that prolotherapy consistently reduced pain and improved function in various ligament injuries

The ensuing pathology, largely consisting of macrophage and lymphocyte infiltration of mainly the spinal cord, recapitulates the inflammatory pathology of acute MS lesions in a number of respects, but differs from MS in important ways: many EAE variants exhibit only limited demyelination confined to the spinal cord white matter, contrasting with extensive brain pathology also prominently affecting cortical gray matter in MS

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However, other conditions can also cause white spots