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However, despite their potential advantages, both retinospheres and retinal organoids suffer from the limitation that RGCs, more so than other retinal neurons, eventually die in culture [60], potentially due to the lack of retrograde transport of survival cues, such as brain-derived neurotrophic factor (BDNF), from central subcortical targets

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IF has been shown to decrease LDL levels by 1 to 47 mg/dL, total cholesterol by 5 to 88 mg/dL, and TG by 364 mg/dL [28]