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The Santa Fe Railroad took a northern route through Flagstaff, and the Southern Pacific traveled the southern route through Tucson

Comment: Several commenters recommended various approaches to improve transparency around how MACs make payment for radiopharmaceuticals, including for CMS to closely monitor and evaluate how MACs make payment for radiopharmaceuticals and to direct MACs to publish the prices of these radiopharmaceuticals and publicly state the specific payment methodology that they use

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Metabolite ratios have been successfully used in newborn screening for inherited metabolic disorders such as phenylketonuria, maple syrup urine disease, and certain disorders of organic acid or of mitochondrial fatty acid metabolism (35, 36) as well as in identifying metabolic underpinnings of more complex, multifactorial biological processes (37, 38)