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Fifth, redesign trials as mechanism-anchored: use biomarker gates for enrollment and co-primary endpoints that pair mechanistic change (e.g., Prx cycling, 2-OH-E, LIP shifts) with clinical benefit, avoiding the trap of ROS lowering without outcome (Drakulic et al

Smeets T, Cornelisse S, Quaedflieg CW, Meyer T, Jelicic M, Merckelbach H

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