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Liver transcriptomics analysis discovered that hepatocyte Cul3 deficiency caused activation of the NRF2 transcriptional network because CRL3 mediated NRF2 protein turnover

(4) Macro-B12 becomes a reasonable consideration when a value is very high, persists over time, comes with no B12 exposure, sits alongside an unrevealing workup, or disagrees with functional markers

Nevertheless, multiple clinical trials testing different cyclic dinucleotides [e.g., BMS-986301 (NCT03956680) or BI 1387446 (NCT04147234)] either alone or in combination with other cancer therapies are currently ongoing and will ultimately determine the future relevance of STING agonists in a clinical setting (www.clinicaltrials.gov)